International Research Training Group 1902

Welcome to the pages of the International Research Training Group 1902

The International Research Training Group (IRTG1902) “Intra- and interorgan communication of the cardiovascular system” is a research alliance of the Heinrich-Heine-Universität Düsseldorf and the Cardiovascular Research Center at the University of Virginia, Charlottesville, USA, dedicated to promote international training of doctoral researchers. Over the last decades it became evident that cardiovascular function is not only the result of a signaling among typical cardiovascular cells such as cardiomyocytes, endothelial and smooth muscle cells. Rather an extensive crosstalk with adjacent parenchymal cells as well as inflammatory cells, erythrocytes, and platelets occurs.

Moreover, the vasculature provides a major communication route for hormones and other humoral factors released by many tissues enabling long distance communication of remote organs. For example, adipokines and myokines, released from adipose tissue and skeletal muscle, may affect cardiovascular
function in health and disease. Otherwise, the failing heart releases many cytokines and growth factors, which affect remote organs (e.g. muscle, adipose tissue, etc.). Thus, extensive intra- and interorgan communication of the cardiovascular system provides the basis for control of organ physiology and pathology on a systemic level.

IRTG1902 adress three key research areas:

  • ATP-pannexin1 mediated communication of blood vessels, erythrocytes, platelets, and fibroblasts, and its function in lung injury and heart and kidney fibrosis.
  • Inflammatory mechanisms in the crosstalk of heart and blood vessels with skeletal muscle, adipose tissue, and inflammatory cells in heart failure and atherosclerosis.
  • cardiovascular remodeling including lymph angiogenesis, cardiac hypertrophy, and aortic aneurysm formation.

The educational program of the IRTG provides doctoral researchers with a profound knowledge in the field of integrative cardiovascular biology at the interface of basic research and clinical science.

Mina Yakoub awarded “Start Up” funding grant from IRTG 1902

Mina Yakoub has two good reasons to celebrate.  He submitted his PhD Thesis in April and has been awarded an IRTG 1902 Postdoc Start Up Funding grant, which he started at the beginning of May.  His PhD research investigating the effect of different diet components on the cardiovascular health was supervised by Dr. Johannes Stegbauer, Department of Experimental Nephrology, University Hospital of Düsseldorf. Short chain fatty acids,...

Program IRTG 1902 & Grk SFB 1116 cancelled!!

Dear All,

In line with the recent email from the Heinrich Heine University President, all IRTG 1902 and SFB 1116 lectures, seminars, workshops and practical courses scheduled up until May 31st have been cancelled.  We are looking into alternative methods for holding these learning events, such as online meeting platforms, so stay tuned and keep well!

Best wishes,

IRTG 1902 & Grk SFB 1116 office



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No actual events

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Spokesman Germany

Prof. Dr. rer. nat. Axel Gödecke

Institute of Cardiovascular Physiology
Heinrich Heine University Düsseldorf
Phone +49 211 81-12670
Fax +49 211 81-12672

Scientific Coordinator

Dr. rer. nat. Sandra Berger

Institut für Herz-Kreislaufphysiologie
Universitätsstr. 1
Building: 22.03.
Floor/Room: Ebene 02.R10
Phone +49 211 81-12673
Fax +49 211 81-12672
Responsible for the content: E-MailIRTG 1902