Ehsan Amin

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PostDoc

Dr. rer. nat. Ehsan Amin

Institute of Neuro- und Sensory Physiology
Phone +49 211 81-02935
Member of the IRTG 1902: October 2013 - December 2016
PhD research project:

Regulation and signaling of endothelial RHO GTPases

 

Supervisor:

PD Dr. Reza Ahmadian

Institute of Biochemistry and Molecular Biology II

Heinrich-Heine Universität Düsseldorf

2nd Supervisor:

Prof. Dr. Georg Groth

Biochemical Plant Physiology

Heinrich-Heine Universität Düsseldorf

3rd Supervisor:

Prof. Dr. Avril Somlyo

Molecular Physiology and Biological Physics,

University of Virginia, Charlottesville, USA

News:

Individual Publications

1. Amin E, Jaiswal M, Derewenda U, Reis K, Nouri K, Koessmeier KT, Aspenström P, Somlyo AV, Dvorsky R, Ahmadian MR (2016) Deciphering the molecular and functional basis of RhoGAP family proteins: A systematic approach towards selective inactivation of Rho family proteins. J Biol Chem 291:20353-71.

2. Becker MS, Müller PM, Bajorat J, Schroeder A, Giaisi M, Amin E, Ahmadian MR, Rocks O, Köhler R, Krammer PH, Li-Weber M (2016) The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration. Oncotarget 7:51908-51921.

3. Nakhaeizadeh H, Amin E, Nakhaei-Rad S, Dvorsky R, Ahmadian MR (2016) The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions. PLoS One 11:e0167145.

4. Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR. (2016) IQGAP1 interaction with RHO family proteins revisited: Kinetic and equilibrium evidence for multiple distinct binding sites. J Biol Chem 291:26364-26376.

5. Dütting S, Heidenreich J, Cherpokova D, Amin E, Zhang SC, Ahmadian MR, Brakebusch C, Nieswandt B (2015) Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse plate-lets. J Thromb Haemost 13:827-38.

6. Nouri K, Moll JM, Milroy LG, Hain A, Dvorsky R, Amin E, Lenders M, Nagel-Steger L, Howe S, Smits SH, Hengel H, Schmitt L, Münk C, Brunsveld L, Ahmadian MR (2015) Biophysical Characterization of Nucleo-phosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11. PLoS One 10:e0143634.

7. Jaiswal M, Dvorsky R, Amin E, Risse SL, Fansa EK, Zhang SC, Taha MS, Gauhar AR, Nakhaei-Rad S, Kor-des C, Koessmeier KT, Cirstea IC, Olayioye MA, Haeussinger D, Ahmadian MR (2014) Functional crosstalk between Ras and Rho pathways: p120RasGAP competitively inhibits the RhoGAP activity of Deleted in Liver Cancer (DLC) tumor suppressors by masking its catalytic arginine finger. J Biol Chem 289:6839-49.

8. Zhang SC, Nouri K, Amin E, Taha MS, Nakhaeizadeh H, Nakhaei-Rad S, Dvorsky R, Ahmadian MR (2014) Classical Rho Proteins: Biochemistryof Molecular Switch Function and Regulation. In: Wittinghofer, A (ed) Ras Superfamily small G Proteins, Biology and Mechanism, Vol. 1 Springer, Chapter 14, pp 327-340.

9. Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Som-lyo AV, Ahmadian MR. (2014) Rho-kinase: regulation, (dys)function, and inhibition. Biol Chem 394:1399-410.

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