International Research Training Group 1902

Welcome to the pages of the International Research Training Group 1902

The International Research Training Group (IRTG1902) “Intra- and interorgan communication of the cardiovascular system” is a research alliance of the Heinrich-Heine-Universität Düsseldorf and the Cardiovascular Research Center at the University of Virginia, Charlottesville, USA, dedicated to promote international training of doctoral researchers. Over the last decades it became evident that cardiovascular function is not only the result of a signaling among typical cardiovascular cells such as cardiomyocytes, endothelial and smooth muscle cells. Rather an extensive crosstalk with adjacent parenchymal cells as well as inflammatory cells, erythrocytes, and platelets occurs.

Moreover, the vasculature provides a major communication route for hormones and other humoral factors released by many tissues enabling long distance communication of remote organs. For example, adipokines and myokines, released from adipose tissue and skeletal muscle, may affect cardiovascular
function in health and disease. Otherwise, the failing heart releases many cytokines and growth factors, which affect remote organs (e.g. muscle, adipose tissue, etc.). Thus, extensive intra- and interorgan communication of the cardiovascular system provides the basis for control of organ physiology and pathology on a systemic level.

IRTG1902 adress three key research areas:

  • ATP-pannexin1 mediated communication of blood vessels, erythrocytes, platelets, and fibroblasts, and its function in lung injury and heart and kidney fibrosis.
  • Inflammatory mechanisms in the crosstalk of heart and blood vessels with skeletal muscle, adipose tissue, and inflammatory cells in heart failure and atherosclerosis.
  • cardiovascular remodeling including lymph angiogenesis, cardiac hypertrophy, and aortic aneurysm formation.

The educational program of the IRTG provides doctoral researchers with a profound knowledge in the field of integrative cardiovascular biology at the interface of basic research and clinical science.

DAAD RISE Internship students at IRTG1902 Projects in Düsseldorf

This summer the International Research Training Group 1902 had the pleasure to welcome three exchange students from University of Virginia (UVA), USA and Simon Fraser University (SFU), Canada.

They were all sponsored by the DAAD RISE program (Research Internships in Science and Engineering) and had opportunity to get an insight into the laboratories here in Düsseldorf and build up a network with various work groups.

We say thank you for...

Philipp Jakobs defended his doctoral thesis successfully!

On July 4th, 2018 Philipp Jakobs successfully defended his doctoral thesis at Heinrich Heine University. He spent three years working on his research in Professor Jojo Haendeler laboratory at the IUF, Leibniz Research Institute for Environmental Medicine.

During his 6 month exchange with the collaborating laboratory of Professor Norbert Leitinger at the University of Virginia (UVA), USA he investigated the influence and regulation of...

Team Building IRTG1902 and SFB1116 on the water

The doctoral researchers of the research training groups enjoyed a team building event on lake Unterbach. In the hot weather the time on the lake was a welcome break from the Lab. The 5-person canoes provided a perfect opportunity to get to know each other and to work together in friendly competition against other teams. 

Datum: Uhrzeit: Veranstaltung:
23.10.18 ǀ 17:00 - 18:30 Progress Report: Lisa Kalfhues and Frederik Barbarino
30.10.18 ǀ 17:00 - 18:30 Progress Report: Felicia Hartmann and Kim Krott
31.10.18 ǀ 16:15 - 17:15 Guest lecture:
Prof. Dr. Thomas Wight
06.11.18 ǀ 17:00 - 18:30 Progress Report: Angelina Misiou and Kirsten Jander
13.11.18 ǀ 17:00 - 18:30 Progress Report: Marcel Buchholzer and Vici Oenarto

Spokesman Germany

Prof. Dr. rer. nat. Axel Gödecke

Institute of Cardiovascular Physiology
Heinrich Heine University Düsseldorf
Phone +49 211 81-12670
Fax +49 211 81-12672

Scientific Coordinator

Dr. rer. nat. Sandra Berger

Institut für Herz-Kreislaufphysiologie
Universitätsstr. 1
Building: 22.03.
Floor/Room: Ebene 00.R56
Phone +49 211 81-12673
Fax +49 211 81-12672
Responsible for the content: E-MailIRTG 1902